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Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines

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dc.contributor.authorSEVER, BELGİN
dc.contributor.authorYılmaz, Nalan
dc.contributor.authorALTINTOP, MEHLİKA DİLEK
dc.contributor.authorAKALIN ÇİFTÇİ, GÜLŞEN
dc.contributor.authorBEYDEMİR, ŞÜKRÜ
dc.contributor.authorÖZDEMİR, AHMET
dc.contributor.authorAhmet Özdemır
dc.contributor.orcid0000-0003-4847-9711
dc.contributor.orcid0000-0002-8159-663X
dc.contributor.orcid0000-0003-3216-1098
dc.contributor.orcid0000-0001-9535-2508
dc.contributor.orcid0000-0003-3667-6902
dc.contributor.orcid0000-0003-0280-5550
dc.date.accessioned2025-11-13T09:08:34Z
dc.date.issued2021-07-09
dc.identifier.doihttps://doi.org/10.1016/j.cbi.2021.109576
dc.identifier.endpage109576
dc.identifier.issn0009-2797
dc.identifier.openalexW3177839994
dc.identifier.startpage109576
dc.identifier.urihttps://hdl.handle.net/11421/575
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2021.109576
dc.identifier.volume345
dc.language.isoen
dc.relation.ispartofChemico-Biological Interactions
dc.rightsrestrictedAccess
dc.subjectAldose reductase
dc.subjectIC50
dc.subjectChemistry
dc.subjectAldose reductase inhibitor
dc.subjectIn silico
dc.subjectCytotoxicity
dc.subjectMoiety
dc.subjectPharmacology
dc.subjectBioavailability
dc.subjectIn vitro
dc.subjectDocking (animal)
dc.subjectStereochemistry
dc.subjectSorbinil
dc.subjectPyrazoline
dc.subjectBiochemistry
dc.subjectEnzyme
dc.subjectMedicine
dc.subjectMedicinal chemistry
dc.subject.sdg3
dc.titleIdentification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
dc.typeArticle
dspace.entity.typePublication
local.authorid.openalexA5040352588
local.authorid.openalexA5021902825
local.authorid.openalexA5048968214
local.authorid.openalexA5059753642
local.authorid.openalexA5081967794
local.authorid.openalexA5100651829

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