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Development and assessment of novel pyrazole–thiadiazol hybrid derivatives as VEGFR-2 inhibitors: design, synthesis, anticancer activity evaluation, molecular docking, and molecular dynamics simulation

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dc.contributor.authorHalimi, Gresa
dc.contributor.authorOSMANİYE, DERYA
dc.contributor.authorÖZKAY, YUSUF
dc.contributor.authorKAPLANCIKLI, ZAFER ASIM
dc.contributor.orcid0000-0002-0499-436X
dc.contributor.orcid0000-0001-5948-1855
dc.contributor.orcid0000-0003-2252-0923
dc.date.accessioned2025-11-13T12:07:56Z
dc.date.issued2024-05-31
dc.identifier.doihttps://doi.org/10.1515/znc-2024-0067
dc.identifier.endpage304
dc.identifier.issn0939-5075
dc.identifier.issue9-10
dc.identifier.openalexW4399238786
dc.identifier.startpage291
dc.identifier.urihttps://hdl.handle.net/11421/9061
dc.identifier.urihttps://doi.org/10.1515/znc-2024-0067
dc.identifier.volume79
dc.language.isoen
dc.relation.ispartofZeitschrift für Naturforschung C
dc.rightsrestrictedAccess
dc.subjectPharmacophore
dc.subjectAngiogenesis
dc.subjectDocking (animal)
dc.subjectChemistry
dc.subjectIn silico
dc.subjectVascular endothelial growth factor
dc.subjectMetastasis
dc.subjectPyrazole
dc.subjectCancer cell
dc.subjectCell growth
dc.subjectCancer research
dc.subjectPharmacology
dc.subjectCancer
dc.subjectBiochemistry
dc.subjectBiology
dc.subjectStereochemistry
dc.subjectVEGF receptors
dc.subjectMedicine
dc.subject.sdg3
dc.titleDevelopment and assessment of novel pyrazole–thiadiazol hybrid derivatives as VEGFR-2 inhibitors: design, synthesis, anticancer activity evaluation, molecular docking, and molecular dynamics simulation
dc.typeArticle
dspace.entity.typePublication
local.authorid.openalexA5098964900
local.authorid.openalexA5017640266
local.authorid.openalexA5079847526
local.authorid.openalexA5060247565

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