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Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition

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dc.contributor.authorYURTTAŞ, LEYLA
dc.contributor.authorSevde Nur Biltekin
dc.contributor.authorLeyla Yurttaş
dc.contributor.authorBarkın Berk
dc.contributor.authorYağmur Özhan
dc.contributor.authorHande Si̇pahi̇
dc.contributor.authorZhan‐Guo Gao
dc.contributor.authorKenneth A. Jacobson
dc.contributor.authorŞeref Demirayak
dc.contributor.orcid0000-0002-5976-676X
dc.contributor.orcid0000-0003-1896-2729
dc.contributor.orcid0000-0002-0957-6044
dc.contributor.orcid0000-0001-6047-2796
dc.contributor.orcid0000-0001-6173-3281
dc.contributor.orcid0000-0001-6482-3143
dc.contributor.orcid0000-0002-6663-524X
dc.contributor.orcid0000-0001-8104-1493
dc.contributor.orcid0000-0002-0841-1299
dc.date.accessioned2025-11-13T10:15:09Z
dc.date.issued2020-12-30
dc.identifier.doi10.1016/j.ejmech.2020.113125
dc.identifier.endpage113125
dc.identifier.issn0223-5234
dc.identifier.openalexW3115872106
dc.identifier.startpage113125
dc.identifier.urihttps://hdl.handle.net/11421/3586
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2020.113125
dc.identifier.volume212
dc.language.isoen
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.rightsopenAccess
dc.subjectChemistry
dc.subjectPharmacophore
dc.subjectIC50
dc.subjectAdenosine receptor
dc.subjectReceptor
dc.subjectCell culture
dc.subjectStereochemistry
dc.subjectPharmacology
dc.subjectPhosphodiesterase
dc.subjectAdenosine
dc.subjectPotency
dc.subjectBiochemistry
dc.subjectIn vitro
dc.subjectEnzyme
dc.subject.sdg3
dc.titleNovel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
dc.typeArticle
dspace.entity.typePublication
local.authorid.openalexA5090129265

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