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Quinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit docking studies

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dc.contributor.authorCem Yamalı
dc.contributor.authorSAĞLIK ÖZKAN, BEGÜM NURPELİN
dc.contributor.authorHalise İnci Gül
dc.contributor.authorLEVENT, SERKAN
dc.contributor.authorMehtap Tuğrak Sakarya
dc.contributor.authorBegüm Nurpelin Sağlık
dc.contributor.authorAbdulilah Ece
dc.contributor.authorGöksun Demirel
dc.contributor.authorMerve Nenni
dc.contributor.authorSerkan Levent
dc.contributor.authorAhmet Cihat ÖNER
dc.contributor.orcid0000-0002-4833-7900
dc.contributor.orcid0000-0001-6164-9602
dc.contributor.orcid0000-0002-6535-6580
dc.contributor.orcid0000-0002-0151-6266
dc.contributor.orcid0000-0002-3087-5145
dc.contributor.orcid0000-0002-2994-5505
dc.contributor.orcid0000-0003-3165-1060
dc.contributor.orcid0000-0003-3692-163X
dc.contributor.orcid0000-0001-6614-4347
dc.date.accessioned2025-11-13T09:38:16Z
dc.date.issued2022-04-21
dc.identifier.doi10.1016/j.bioorg.2022.105822
dc.identifier.endpage105822
dc.identifier.issn0045-2068
dc.identifier.openalexW4224218747
dc.identifier.pubmed35500503
dc.identifier.scopus2-s2.0-85129231128
dc.identifier.startpage105822
dc.identifier.urihttps://hdl.handle.net/11421/1726
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2022.105822
dc.identifier.volume124
dc.identifier.wos000800387400002
dc.language.isoen
dc.relation.ispartofBioorganic Chemistry
dc.rightsrestrictedAccess
dc.subjectChemistry
dc.subjectMonoamine oxidase
dc.subjectMoclobemide
dc.subjectDocking (animal)
dc.subjectIn silico
dc.subjectIC50
dc.subjectStereochemistry
dc.subjectEnzyme
dc.subjectLipinski's rule of five
dc.subjectPharmacology
dc.subjectMonoamine neurotransmitter
dc.subjectToxicity
dc.subjectMonoamine oxidase B
dc.subjectBiochemistry
dc.subjectIn vitro
dc.subjectReceptor
dc.subjectOrganic chemistry
dc.subject.sdg6
dc.titleQuinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit docking studies
dc.typeArticle
dspace.entity.typePublication
local.authorid.openalexA5074136342
local.authorid.openalexA5075534569

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